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產(chǎn)品名稱: Recombinant Human IGF-1
產(chǎn)品型號: 100-11-20
產(chǎn)品展商: Peprotech
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Recombinant Human IGF-1，中文名稱：重組人胰島素樣生長因子-1(IGF-1)，規(guī)格：20ug
Recombinant Human IGF-1
的詳細(xì)介紹
Recombinant Human IGF-1：Description :
The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds.
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